On November 7th, 2017, the Ethics Committee of the Universidad Central del Ecuador formally approved the ZIKAction Congenital Microcephaly Case-Control Study protocol. This prospective study, focused on estimating the risk of congenital microcephaly associated with Zika virus, dengue or chikungunya infection, will be led by Dra. Greta Miño from Hospital del Niño Francisco Icaza Bustamante of Guayaquil and Dr. Toni Soriano from University Hospital Vall d’Hebron in Barcelona as co-lead of the ZIKA-PED work package.