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Publications

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Researching Zika in pregnancy: lessons for global preparedness

By: Ades AE, Thorne C, Soriano-Arandes A, et al.

Our understanding of congenital infections is based on prospective studies of women infected during pregnancy. The EU has funded three consortia to study Zika virus, each including a prospective study of pregnant women. Another multi-centre study has been funded by the US National Institutes of Health. This Personal View describes the study designs required to research Zika virus, and questions whether funding academics in the EU and USA to work with collaborators in outbreak areas is an effective strategy.

Published in: Lancet Infect Dis. 2020 Feb 18

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Severity and outcomes of Dengue in hospitalized children from five hospitals in Jamaica during the 2018-2019 epidemic: is this due to antibody dependent immune enhancement from ZIKA virus exposure?

By Lue A.

Published in: Oral presentation at 3rd international Conference on Zika Virus and aedes related infections, February 13th – 16th, 2020– Washington DC, USA.

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Trends in Dengue – The Jamaican experience

By Webster-Kerr K.

Published in: Oral presentation at 3rd international Conference on Zika Virus and aedes related infections, February 13th – 16th, 2020– Washington DC, USA.

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Overview and preliminary results of the ZIKAction vertical transmission study in Jamaica

By Celia DC Christie

Published in: Oral presentation at 3rd international Conference on Zika Virus and aedes related infections, February 13th – 16th, 2020– Washington DC, USA.

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Return of the founder Chikungunya virus to its place of introduction into Brazil is revealed by genomic characterization of exanthematic disease cases

By Pereira Gusmão Maia Z, Mota Pereira F, do Carmo Said RF, et al.

Between June 2017 and August 2018, several municipalities located in Bahia state (Brazil) reported a large increase in the number of patients presenting with febrile illness similar to that of arboviral infections. Using a combination of portable whole genome sequencing, molecular clock and epidemiological analyses, we revealed the return of the CHIKV-ECSA genotype into Bahia.

Published in: Emerg Microbes Infect. 2020;9(1):53-57

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Modulated Zika virus NS1 conjugate offers advantages for accurate detection of Zika virus specific antibody in double antigen binding and Ig capture enzyme immunoassays

By Tedder RS, Dicks S, Ijaz S, et al.

The accurate diagnosis and seroprevalence investigations of Zika virus (ZKV) infections remain complex due to cross reactivity with other flaviviruses. Comparing DABA and G capture assays using quenched and unquenched conjugates in comparison with EuroimmunZ early in the course of PCR-confirmed infection indicated that a significant component of the apparent early anti-ZIKA antibody response is likely to be due to a Zika virus-driven anamnestic anti-Dengue virus response. The increased specificity provided by homologous antigen quenching is likely to provide a significant improvement in sero-diagnostics and to be of clinical value.

Published in: PLoS One. 2019;14(8):e0215708

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Factors predicting the severity of dengue in patients with warning signs in Rio de Janeiro, Brazil (1986–2012)

By Goncalves BS, Nogueira RMR, Bispo de Filippis AM, Horta MAP

Since 1981, >12 million cases of dengue have been reported in Brazil. Early prediction of severe dengue with no warning signs is crucial to avoid progression to severe dengue. Here we aimed to identify early markers of dengue severity and characterize dengue infection in patients in Rio de Janeiro.

Published in: Trans R Soc Trop Med Hyg. 2019;113(11):670-677

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Follow up of Children with Confirmed Perinatal Zika Virus (ZIKV) Exposure: The First 2 years-experience in the Costa Rican Tertiary Pediatric Hospital

By H Brenes-Chacón, ML Ávila-Agüero, K Camacho-Badilla, G Naranjo-Zuñiga, A Benavides-Lara, A Soriano-Fallas

Poster presented at the ID Week, Washington DC, October 2nd – 6th 2019

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Yellow Fever virus reemergence and spread in southeast Brazil, 2016-2019

By Giovannetti M, de Mendonca MCL, Fonseca V, et al.

The recent reemergence of yellow fever virus (YFV) in Brazil has raised serious concerns due to the rapid dissemination of the virus in the southeastern region. To better understand YFV genetic diversity and dynamics during the recent outbreak in southeastern Brazil, we generated 18 complete and nearly complete genomes from the peak of the epidemic curve from nonhuman primates (NHPs) and human infected cases across the Espírito Santo and Rio de Janeiro states.

Published in: J Virol. 2019;94(1). pii: e01623-19

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By Tedder RS, Dicks S, Ijaz S, et al. 

The accurate diagnosis and seroprevalence investigations of Zika virus (ZKV) infections remain complex due to cross reactivity with other flaviviruses. Two assay formats, both using labelled Zika virus NS1 antigen as a revealing agent (a double antigen binding assay, DABA, and an immunoglobulin Ig capture assay, G capture) were initially developed and compared with the indirect EuroimmunZ assay for the detection of anti-Zika antibody.

Published in: PLoS One. 2019;14(8):e0215708

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