ZIKA-PED aims to conduct prospective cohort studies among children with congenital and postnatally acquired ZIKV infection in Central and South America and the Caribbean to assess:
- 1) Clinical forms and natural history of these infections
- 2) Incidence of neurological disorders in first two years of life
- 3) Feasibility of long-term follow-up of these children for monitoring of late sequelae.
WP2 is led by Irmandade da Santa Casa de Misericordia de Sao Paulo and co-led Institut Catala de la Salut.
The figure below shows the flow of subjects involved in these studies. Infants born to mothers participating in ZIKA-VT studies will be included, as well as children who present with ZIKV infection at hospitals in both ZIKV endemic and non-endemic areas.
Specific tasks in this WP include; study staff training, enrolment into studies, clinical developmental follow-up of children with both congenital and postnatally acquired ZIKV infection, statistical analysis and assessment of feasibility of long-term follow-up.