Zika-Patho aimed to investigate the pathogenic mechanism of Zika vertical transmission in pregnant women.
To achieve this goal, this research area associated different translational models such as immortalized placental cell lines, explants of human placenta and in vivo studies with highly specialized laboratory techniques. This combination provided valuable insights into Zika pathogenesis at the level of the placenta.
Activities in this area
- Definition of host and viral factors driving Zika infection in human placental tissue.
- Determination of the role of the host lipid profile as a risk factor of Zika vertical transmission in a rodent model.
- Study of teratogenic and abortogenic potential of ZIKV infection at different gestational times in sheep.