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Investigating vertical transmission of chikungunya, dengue and zika virus infection: a prospective observational cohort study of pregnant women and infants in Jamaica

By CD Christie, C Thorne, J Anzinger, H Bailey, et al.

Poster presented at the International Symposium on Zika Virus Research, held in Marseille – France, on June 4th – 6th 2018

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Symptomatic Zika Virus Infection in Infants, Children, and Adolescents Living in Puerto Rico

By Read JS, Torres-Velasquez B, Lorenzi O, et al.

This study represents the largest study to date of ZIKV infection in the pediatric population. Most children infected with ZIKV had fever, rash, and conjunctival hyperemia. The children usually presented for evaluation at fewer than 3 days after the onset of symptoms. Viral loads for ZIKV were higher in serum vs urine specimens. Median viral loads in serum specimens differed significantly according to the number of days after the onset of symptoms.

Published in: JAMA Pediatr. 2018;172(7):686-693.

 

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Genetic evidence of Zika virus in mother’s breast milk and body fluids of a newborn with severe congenital defects

By Giovanetti M, Goes de Jesus J, Lima de Maia M, Junior JX, et al.

On the basis of the upsurge in the number of newborns with neurologic disorders in the northeast, in November 2015 the Brazilian Ministry of Health declared a public health emergency of national concern. On the basis of evidence for a potential association between microcephaly and other neurologic disorders and Zika virus (ZIKV) infection, the World Health Organization declared a public health emergency of international concern on 1 February 2016. Here we report genetic evidence of ZIKV RNA in the mother’s breast milk and in the serum and urine of a newborn with severe congenital defects.

Published in: Clin Microbiol Infect. 2018 Oct;24(10):1111-1112.

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Clinical and Laboratory Profile of Zika and Dengue Infected Patients: Lessons Learned From the Co-circulation of Dengue, Zika and Chikungunya in Brazil

By Azeredo EL, Dos Santos FB, et al.

The current triple epidemic caused by dengue, zika and chikungunya constitutes a serious health problem in Brazil. The aim of this study was to investigate acute samples (up to the 7 days of symptoms) from patients presenting acute fever syndrome suspected as arboviral infection and characterize the clinical and laboratorial profile during the co-circulation of dengue, zika and chikungunya in Campo Grande, Mato Grosso do Sul (MS), midwest region of Brazil.

Published in: PLoS Curr. 2018 Feb 15;10.

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What we know and what we don’t know about perinatal Zika virus infection: A systematic review

By Soriano-Arandes A, Rivero-Calle I, Nastouli E, et al.

Zika virus (ZIKV) infection has caused the most challenging worldwide infectious epidemic outbreak in recent months. ZIKV causes microcephaly and other congenital malformations. There is a need to perform updated systematic reviews on ZIKV infection periodically because this epidemic is bringing up new evidence with extraordinary speed.

 

Published in: Expert Rev Anti Infect Ther. 2018 Mar;16(3):243-254

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Evidence for Mother-to-Child Transmission of Zika Virus Through Breast Milk

By Gabriela M Blohm, John A Lednicky, Marilianna Márquez, Sarah K White, Julia C Loeb, Carlos A Pacheco, David J Nolan, Taylor Paisie, Marco Salemi, Alfonso J Rodríguez-Morales, J Glenn Morris, Juliet R C Pulliam, Alberto E Paniz-Mondolfi

Zikavirus (ZIKV) is an emerging viral pathogen that continues to spread throughout different regions of the world. Herein we report a case that provides further evidence that ZIKV transmission can occur through breastfeeding by providing a detailed clinical, genomic, and virological case-based description.

Published in: Clin Infect Dis. 2018 Mar 19;66(7):1120-1121.

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Human T cell responses to Dengue and Zika virus infection compared to Dengue/Zika coinfection

By Badolato-Corrêa J, Sánchez-Arcila JC, et al.

Zika virus (ZIKV) and dengue virus (DENV) co-circulated during latest outbreaks in Brazil, hence, it is important to evaluate the host cross-reactive immune responses to these viruses. So far, little is known about human T cell responses to ZIKV and no reports detail adaptive immune responses during DENV/ZIKV coinfection.

Published in: Immun Inflamm Dis. 2018 Jun; 6(2): 194–206.

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Meningo-encephalo-myelitis in Children during the Zika Virus Epidemic in Grenada

By Nelson B, Melbourne-Chambers R, Christie CDC

Zika Virus is neurotropic. We report two children from the Caribbean island of Grenada, a three-year-old with acute neuro-inflammation who had intractable seizures, meningo-encephalitis, CSF pleocytosis and Zika IgM positive acute serology and a four-year-old with acute demyelinating encephalomyelitis manifesting as generalized seizures, optic neuritis, diffuse cerebral dysfunction, encephalopathy, impaired speech and ataxia who also had CSF pleocytosis as well as Zika IgM and dengue IgM positive acute serologies. Both cases occurred during the 2016 Zika and Dengue fever epidemic in Grenada. Both children recovered completely. The etiologic role of the Zika and Dengue arboviruses is discussed.

Published in: West Indian Med J. Published Online: December 20, 2017 (doi:10.7727/wimj.2017.227) 

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Consequences of perinatal infections with rubella, measles, and mumps

By Schwarz ER.

Measles, mumps, and rubella have recently taken the stage as re-emerging diseases of public health importance-particularly in regards to the consequences seen with perinatal infections. Effective vaccination strategies have successfully reduced the spread of measles, mumps, and rubella in the United States, but a current trend of increased vaccination hesitancy, fear of vaccine safety, and spread of misconceptions surrounding the science of vaccines have led to a relative resurgence of these diseases in the developed world. This article aims to explore why measles, mumps, and rubella should continue to be on the radar of medical professionals, and why the study of these diseases is important for understanding other teratogenic viruses of public health importance.

Published in: Curr Opin Virol. 2017;27:71-77

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