Metabolomic studies
Three studies been completed on Metabolomic analyses of investigating the metabolomic profile of newborns exposed to ZIKV:
Study 1 Lipidomic: Umbilical cord plasma lipids associated with ZIKV infection and microcephaly
These describe the plasma lipidome in ZIKV exposed newborns with microcephaly and normocephaly in comparison to non-infected controls, based on cord blood samples collected from 30 participants. Preliminary results revealed significant changes in plasma lipidome in ZIKV exposed newborns relative to controls. Normocephalic ZIKV exposed newborns displayed elevated plasma concentrations of lysophosphatidylcholine, and reduced content of several triglycerides esterified to linoleic acid and free cholesterol as compared to controls.
Results
- The study has been described in the manuscript Lipidomic Analysis Reveals Serum Alteration of Plasmalogens in Patients Infected With ZIKA Virus”, Queiroz A. et al., Frontiers in Microbiology
Study 2 Metabolomic study on newborns with ZIKV infection
The effects of ZIKV infection and microcephaly were investigated by untargeted metabolomics using gas chromatography-mass spectrometry (GC-MS) analysis. Overall, important reductions in contents of amino acids and derivatives, carbohydrates and conjugates, organic and fatty acids were found when groups such as ZPMP and ZPMN were compared to the control group (ZNMN).
Study 3: Plasma lipidome profiling of newborns with antenatal exposure to ZIKV
Plasma lipidome profiling was performed in both normocephalic and microcephalic newborns with antenatal ZIKV exposure and compared to noninfected controls. Data reveal that plasma lipidome alterations associated with antenatal exposure to ZIKV could contribute to identification and monitoring of the wide spectrum of clinical phenotypes at birth and further, during childhood.
