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Publications

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Past and future spread of the arbovirus vectors Aedes aegypti and Aedes albopictus

By Kraemer MUG, Reiner RC Jr, Brady OJ, et al. 

 

The global population at risk from mosquito-borne diseases—including dengue, yellow fever, chikungunya and Zika—is expanding in concert with changes in the distribution of two key vectors: Aedes aegypti and Aedes albopictus. The distribution of these species is largely driven by both human movement and the presence of suitable climate. Using statistical mapping techniques, we show that human movement patterns explain the spread of both species in Europe and the United States following their introduction. We find that the spread of Ae. aegypti is characterized by long distance importations, while Ae. albopictus has expanded more along the fringes of its distribution. We describe these processes and predict the future distributions of both species in response to accelerating urbanization, connectivity and climate change. Global surveillance and control efforts that aim to mitigate the spread of chikungunya, dengue, yellow fever and Zika viruses must consider the so far unabated spread of these mosquitos. Our maps and predictions offer an opportunity to strategically target surveillance and control programmes and thereby augment efforts to reduce arbovirus burden in human populations globally.

Published in: Nat Microbiol. 2019; 4(5):900.

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Immunoglobulin-like Domain of HsFcμR as a Capture Molecule for Detection of Crimean-Congo Hemorrhagic Fever Virus- and Zika Virus-Specific IgM Antibodies

By Rackow A, Ehmen C, von Possel R, et al.

The cellular surface molecule HsTOSO/ FAIM3/HsFcR has been identified as an IgM-specific Fc receptor expressed on lymphocytes. Here, we show that its extracellular immunoglobulin-like domain (HsFcRIgl) specifically binds to IgM/antigen immune complexes (ICs) and exploit this property for the development of novel detection systems for IgM antibodies directed against Crimean-Congo hemorrhagic fever virus (CCHFV) and Zika virus (ZIKV).

Published in: Clin Chem. 2019; 65(3): 451-461.

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Late Identification of Chikungunya Virus in the Central Nervous System of a 2-Month-Old Infant: Persistence of Maternal-Neonatal Infection?

By Di Maio Ferreira FCPA, da Silva ASV, Bispo de Filippis AM, Brasil P.

We report here a probable case of vertical transmission of chikungunya infection with confirmed maternal viremia close to labor that led to severe infection in the newborn. The newborn progressed with cutaneous lesions and irritability 2 months after vertical transmission, when chikungunya virus was detected in the infant’s CSF by a molecular diagnostic test (real-time polymerase chain reaction).

Published in: J Pediatric Infect Dis Soc. 2019 Jan 18.

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Islands as Hotspots for Emerging Mosquito-Borne Viruses: A One-Health Perspective

By Mavian C, Dulcey M, Munoz O, Salemi M, Vittor AY, Capua I.

Within the context of the One Health approach, this review highlights how the emergence of arboviruses in tropical islands is linked to the complex interplay between their unique ecological settings and to the recent changes in local and global sociodemographic patterns. The authors also advocate for greater coordination between stakeholders in developing novel prevention and mitigation approaches for an intractable problem.

Published in: Viruses. 2019; 11(1):11.

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Zika Virus Infection and Differential Diagnosis in a Cohort of HIV-Infected Patients

By Calvet GA, Brasil P, Siqueira AM, et al.

Zika virus (ZIKV) emergence in South America revealed the lack of knowledge regarding clinical manifestations in HIV-infected individuals. We described the clinical characteristics, laboratory manifestations, differential diagnosis, and outcome of ZIKV infection in a large, single-center cohort of HIV-infected patients.

Published in: J Acquir Immune Defic Syndr. 2018 Oct 1;79(2):237-243.

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Seroprevalence of Dengue, Chikungunya and Zika Viruses in an Antenatal Population in the Greater Kingston Metropolitan Region of Jamaica

By Joshua Anzinger, University Of the West Indies, Kingston – Jamaica

The poster was presented at the 2nd International Conference on Zika Virus and Aedes Related Infections in Tallinn, Estonia on June 14th – 17th 2018.

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Investigating vertical transmission of chikungunya, dengue and zika virus infection: a prospective observational cohort study of pregnant women and infants in Jamaica

By CD Christie, C Thorne, J Anzinger, H Bailey, et al.

Poster presented at the International Symposium on Zika Virus Research, held in Marseille – France, on June 4th – 6th 2018

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Symptomatic Zika Virus Infection in Infants, Children, and Adolescents Living in Puerto Rico

By Read JS, Torres-Velasquez B, Lorenzi O, et al.

This study represents the largest study to date of ZIKV infection in the pediatric population. Most children infected with ZIKV had fever, rash, and conjunctival hyperemia. The children usually presented for evaluation at fewer than 3 days after the onset of symptoms. Viral loads for ZIKV were higher in serum vs urine specimens. Median viral loads in serum specimens differed significantly according to the number of days after the onset of symptoms.

Published in: JAMA Pediatr. 2018;172(7):686-693.

 

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Genetic evidence of Zika virus in mother’s breast milk and body fluids of a newborn with severe congenital defects

By Giovanetti M, Goes de Jesus J, Lima de Maia M, Junior JX, et al.

On the basis of the upsurge in the number of newborns with neurologic disorders in the northeast, in November 2015 the Brazilian Ministry of Health declared a public health emergency of national concern. On the basis of evidence for a potential association between microcephaly and other neurologic disorders and Zika virus (ZIKV) infection, the World Health Organization declared a public health emergency of international concern on 1 February 2016. Here we report genetic evidence of ZIKV RNA in the mother’s breast milk and in the serum and urine of a newborn with severe congenital defects.

Published in: Clin Microbiol Infect. 2018 Oct;24(10):1111-1112.

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Clinical and Laboratory Profile of Zika and Dengue Infected Patients: Lessons Learned From the Co-circulation of Dengue, Zika and Chikungunya in Brazil

By Azeredo EL, Dos Santos FB, et al.

The current triple epidemic caused by dengue, zika and chikungunya constitutes a serious health problem in Brazil. The aim of this study was to investigate acute samples (up to the 7 days of symptoms) from patients presenting acute fever syndrome suspected as arboviral infection and characterize the clinical and laboratorial profile during the co-circulation of dengue, zika and chikungunya in Campo Grande, Mato Grosso do Sul (MS), midwest region of Brazil.

Published in: PLoS Curr. 2018 Feb 15;10.

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