All fields are required.

Close Appointment form

Publications

icon
Return of the founder Chikungunya virus to its place of introduction into Brazil is revealed by genomic characterization of exanthematic disease cases

By Pereira Gusmão Maia Z, Mota Pereira F, do Carmo Said RF, et al.

Between June 2017 and August 2018, several municipalities located in Bahia state (Brazil) reported a large increase in the number of patients presenting with febrile illness similar to that of arboviral infections. Using a combination of portable whole genome sequencing, molecular clock and epidemiological analyses, we revealed the return of the CHIKV-ECSA genotype into Bahia.

Published in: Emerg Microbes Infect. 2020;9(1):53-57

Read the publication
icon
Factors predicting the severity of dengue in patients with warning signs in Rio de Janeiro, Brazil (1986–2012)

By Goncalves BS, Nogueira RMR, Bispo de Filippis AM, Horta MAP

Since 1981, >12 million cases of dengue have been reported in Brazil. Early prediction of severe dengue with no warning signs is crucial to avoid progression to severe dengue. Here we aimed to identify early markers of dengue severity and characterize dengue infection in patients in Rio de Janeiro.

Published in: Trans R Soc Trop Med Hyg. 2019;113(11):670-677

icon
Follow up of Children with Confirmed Perinatal Zika Virus (ZIKV) Exposure: The First 2 years-experience in the Costa Rican Tertiary Pediatric Hospital

By H Brenes-Chacón, ML Ávila-Agüero, K Camacho-Badilla, G Naranjo-Zuñiga, A Benavides-Lara, A Soriano-Fallas

Poster presented at the ID Week, Washington DC, October 2nd – 6th 2019

Read the publication
icon
Yellow Fever virus reemergence and spread in southeast Brazil, 2016-2019

By Giovannetti M, de Mendonca MCL, Fonseca V, et al.

The recent reemergence of yellow fever virus (YFV) in Brazil has raised serious concerns due to the rapid dissemination of the virus in the southeastern region. To better understand YFV genetic diversity and dynamics during the recent outbreak in southeastern Brazil, we generated 18 complete and nearly complete genomes from the peak of the epidemic curve from nonhuman primates (NHPs) and human infected cases across the Espírito Santo and Rio de Janeiro states.

Published in: J Virol. 2019;94(1). pii: e01623-19

icon

By Tedder RS, Dicks S, Ijaz S, et al. 

The accurate diagnosis and seroprevalence investigations of Zika virus (ZKV) infections remain complex due to cross reactivity with other flaviviruses. Two assay formats, both using labelled Zika virus NS1 antigen as a revealing agent (a double antigen binding assay, DABA, and an immunoglobulin Ig capture assay, G capture) were initially developed and compared with the indirect EuroimmunZ assay for the detection of anti-Zika antibody.

Published in: PLoS One. 2019;14(8):e0215708

Read the publication
icon
Re-introduction of dengue virus serotype 2 in the state of Rio de Janeiro after almost a decade of epidemiological silence

By Torres MC, de Bruycker Nogueira F, Fernandes CA, et al.

The Asian/American genotype of dengue virus serotype 2 (DENV-2) has been introduced in Brazil through the state of Rio de Janeiro around 1990, and since then it has been spreading and evolving, leading to several waves of dengue epidemics throughout the country that cause a major public health problem. Of particular interest has been the epidemic of 2008, whose highest impact was evidenced in the state of Rio de Janeiro, with a higher number of severe cases and mortality rate, compared to previous outbreaks.

Published in: PLoS One. 2019;14(12):e0225879

Read the publication
icon
Experimental infection of pregnant female sheep with Zika Virus during early gestation

By Schwarz ER, Pozor MA, Pu R, et al.

Zika virus (ZIKV) is a vertically and sexually transmissible virus resulting in severe congenital malformation. The goal of this study was to develop an ovine model of ZIKV infection

Published in: Viruses. 2019;11(9)

Read the publication
icon
Pregnancy outcomes after maternal Zika virus infection in a non-endemic region: prospective cohort study

By Rodó C, Suy A, Sulleiro E, et al. 

The aim was to describe pregnancy outcomes after Zika virus (ZIKV) infection in a non-endemic region. According to the Spanish protocol issued after the ZIKV outbreak in Brazil in 2015, all pregnant women who had travelled to high-burden countries were screened for ZIKV. Serological and molecular tests were used to identify ZIKV-infected pregnant women. They were classified as confirmed ZIKV infection when reverse transcription (RT) PCR tested positive, or probable ZIKV infection when ZIKV immunoglobulin M and/or immunoglobulin G and ZIKV plaque reduction neutralization tests were positive. Women found positive using molecular or serological tests were prospectively followed-up with ultrasound scans and neurosonograms on a monthly basis until delivery; magnetic resonance imaging and amniotic fluid testing were performed after signed informed consent. Samples of placenta, and fetal and neonatal tissues were obtained. The prevalence of perinatal adverse outcomes for women with ZIKV-confirmed infection was 33.3%. Amniocentesis for ZIKV RT-PCR is recommended when fetal abnormalities are found. Intensive prenatal and postnatal follow-up of ZIKV-infected pregnancies is advised in confirmed cases.

Published in: Clin Microbiol Infect. 2019;25(5):633.e5-633.e9

 

icon
Screening for Zika virus infection in 1057 potentially exposed pregnant women, Catalonia (northeastern Spain)

By Sulleiro E, Rando A, Alejo I, et al.

Published in: Travel Med Infect Dis. 2019;29:69-71

icon
Development of secondary microcephaly after delivery: possible consequence of mother-baby transmission of Zika Virus in breast milk

By Siqueira Mello A, Pascalicchio Bertozzi APA, Rodrigues MMD, et al.

The Zika virus is an arbovirus that has as main source of transmission the bite of infected insects of the genus Aedes and has been associated with cases of congenital malformation and microcephaly in neonates. However, other sources of transmission have been identified since the emergence of this virus in the world population, such as vertical transmission by semen and possibly other body fluids such as vaginal secretion and breast milk.

Published in: Am J Case Rep. 2019:20:723-725

Read the publication