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What we know and what we don’t know about perinatal Zika virus infection: A systematic review

By Soriano-Arandes A, Rivero-Calle I, Nastouli E, et al.

Zika virus (ZIKV) infection has caused the most challenging worldwide infectious epidemic outbreak in recent months. ZIKV causes microcephaly and other congenital malformations. There is a need to perform updated systematic reviews on ZIKV infection periodically because this epidemic is bringing up new evidence with extraordinary speed.

 

Published in: Expert Review of Anti-infective Therapy Vol. 0, Iss. ja, 2018

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Evidence for Mother-to-Child Transmission of Zika Virus Through Breast Milk

By Gabriela M Blohm, John A Lednicky, Marilianna Márquez, Sarah K White, Julia C Loeb, Carlos A Pacheco, David J Nolan, Taylor Paisie, Marco Salemi, Alfonso J Rodríguez-Morales, J Glenn Morris, Juliet R C Pulliam, Alberto E Paniz-Mondolfi

Zikavirus (ZIKV) is an emerging viral pathogen that continues to spread throughout different regions of the world. Herein we report a case that provides further evidence that ZIKV transmission can occur through breastfeeding by providing a detailed clinical, genomic, and virological case-based description.

Published in: Clinical Infectious Diseases, cix968 https://doi.org/10.1093/cid/cix968 

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Meningo-encephalo-myelitis in Children during the Zika Virus Epidemic in Grenada

By Nelson B, Melbourne-Chambers R, Christie CDC

Zika Virus is neurotropic. We report two children from the Caribbean island of Grenada, a three-year-old with acute neuro-inflammation who had intractable seizures, meningo-encephalitis, CSF pleocytosis and Zika IgM positive acute serology and a four-year-old with acute demyelinating encephalomyelitis manifesting as generalized seizures, optic neuritis, diffuse cerebral dysfunction, encephalopathy, impaired speech and ataxia who also had CSF pleocytosis as well as Zika IgM and dengue IgM positive acute serologies. Both cases occurred during the 2016 Zika and Dengue fever epidemic in Grenada. Both children recovered completely. The etiologic role of the Zika and Dengue arboviruses is discussed.

Published in: West Indian Med J. Published Online: December 20, 2017 (doi:10.7727/wimj.2017.227) 

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Neurologic Complications Associated With the Zika Virus in Brazilian Adults

By da Silva IRF, Frontera JA, Bispo de Filippis AM, Nascimento OJMD

Importance:  There are no prospective cohort studies assessing the incidence and spectrum of neurologic manifestations secondary to Zika virus (ZIKV) infection in adults.

Objective:  To evaluate the rates of acute ZIKV infection among patients hospitalized with Guillain-Barré syndrome (GBS), meningoencephalitis, or transverse myelitis.

Published in: JAMA Neurol. 2017;74(10):1190–1198. doi:10.1001/jamaneurol.2017.1703

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Zika genomics urgently need standardized and curated reference sequences

By Theys K, Libin P, Dallmeier K, et al.

In this letter, the authors address the need for curation and standardized annotation of ZIKV reference genomes in order to guide researchers and clinicians in genomic analyses and the translation of research findings.

Published in: PLoS Pathog. 2017;13(9):e1006528

 

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Neurologic Complications Associated With the Zika Virus in Brazilian Adults

By Da Silva IRF, Frontera JA, Bispo de Filippis AM, Nascimento OJMD; RIO-GBS-ZIKV Research Group. 

There are no prospective cohort studies assessing the incidence and spectrum of neurologic manifestations secondary to Zika virus (ZIKV) infection in adults. The article reports on the observational cohort study whose objective was to evaluate the rates of acute ZIKV infection among patients hospitalized with Guillain-Barré syndrome (GBS), meningoencephalitis, or transverse myelitis.

Published in: JAMA Neurol. 2017 Aug 14.

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Antibody-based assay discriminates Zika virus infection from other flaviviruses

By Balmaseda A, Stettler K, Medialdea-Carrera R, Collado D, Jin X, Zambrana JV, Jaconi S, Cameroni E, Saborio S, Rovida F, Percivalle E, Ijaz S, Dicks S, Ushiro-Lumb I, Barzon L, Siqueira PBrown DWG, Baldanti F, Tedder R, Zambon M, de Filippis AMB, Harris E, Corti D.

Zika virus (ZIKV) is a mosquito-borne flavivirus that emerged recently as a global health threat, causing a pandemic in the Americas. ZIKV infection mostly causes mild disease, but is linked to devastating congenital birth defects and Guillain-Barré syndrome in adults. The high level of cross-reactivity among flaviviruses and their cocirculation has complicated serological approaches to differentially detect ZIKV and dengue virus (DENV) infections, accentuating the urgent need for a specific and sensitive serological test. We previously generated a ZIKV nonstructural protein 1 (NS1)-specific human monoclonal antibody, which we used to develop an NS1-based competition ELISA. Well-characterized samples from RT-PCR-confirmed patients with Zika and individuals exposed to other flavivirus infections or vaccination were used in a comprehensive analysis to determine the sensitivity and specificity of the NS1 blockade-of-binding (BOB) assay, which was established in laboratories in five countries (Nicaragua, Brazil, Italy, United Kingdom, and Switzerland). Of 158 sera/plasma from RT-PCR-confirmed ZIKV infections, 145 (91.8%) yielded greater than 50% inhibition. Of 171 patients with primary or secondary DENV infections, 152 (88.9%) scored negative. When the control group was extended to patients infected by other flaviviruses, other viruses, or healthy donors (n = 540), the specificity was 95.9%. We also analyzed longitudinal samples from DENV-immune and DENV-naive ZIKV infections and found inhibition was achieved within 10 d postonset of illness and maintained over time. Thus, the Zika NS1 BOB assay is sensitive, specific, robust, simple, low-cost, and accessible, and can detect recent and past ZIKV infections for surveillance, seroprevalence studies, and intervention trials.

Published in: Proc Natl Acad Sci U S A. 2017Aug 1;114(31):8384-8389.

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Accuracy of Zika virus disease case definition during simultaneous Dengue and Chikungunya epidemics

By Braga JU, Bressan C, Dalvi APR, Calvet GA, Daumas RP, Rodrigues N, Wakimoto M, Nogueira RMR, Nielsen-Saines K, Brito C, Bispo de Filippis AM, Brasil P

Zika is a new disease in the American continent and its surveillance is of utmost importance, especially because of its ability to cause neurological manifestations as Guillain-Barré syndrome and serious congenital malformations through vertical transmission. The detection of suspected cases by the surveillance system depends on the case definition adopted. As the laboratory diagnosis of Zika infection still relies on the use of expensive and complex molecular techniques with low sensitivity due to a narrow window of detection, most suspected cases are not confirmed by laboratory tests, mainly reserved for pregnant women and newborns. In this context, an accurate definition of a suspected Zika case is crucial in order for the surveillance system to gauge the magnitude of an epidemic.

Published in: PLoS One. 2017 Jun 26;12(6):e0179725. 

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Zika virus infection-associated acute transient polyneuritis

By Nascimento OJM, Frontera JA, Amitrano DA, Bispo de Filippis AM, Da Silva IRF; RIO-GBS-ZIKV Research Group. 

This article describes a case series of 3 patients admitted to a tertiary hospital in Rio de Janeiro during the 2016 outbreak of Zika virus infection in Brazil.

Published in: Neurology 2017 Jun 13;88(24):2330-2332.

 

 

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Trends of Microcephaly and Severe Arthrogryposis in Three Urban Hospitals following the Zika, Chikungunya and Dengue Fever Epidemics of 2016 in Jamaica

By James-Powell T., Brown Y., Christie CDC., Melbourne-Chambers R., Moore JT., Morgan O., Butler B., Swaby K., Garbutt A., Anzinger J., Pierre RB., Onyonyor A., Bryan L., Palmer PM, Mitchell P., Johnson P., Bishop K., Jaggon JR., De La Haye W. 

Jamaica experienced its maiden Zika virus (ZIKV) epidemic in 2016, while dengue (serotypes 3 and 4) and chikungunya were also circulating. In this article, we describe initial trends in microcephaly and arthrogryposis observed by the clinicians from three urban birthing facilities during late 2016 to early 2017.

Published in: West Indian Medical Journal, 2017; 66:10-19 and Epub-ahead-of-print, 12 Jun, 2017; DOI 10.7727/wimj.2017.124. 

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